INSICA – About us
The INSICA-Brain Network (we recently extended this network to include brain cancers – International
Network for Research on Sinonasal Cancer, Nasopharyngeal Cancer, Skull Base Tumors and Brain
Cancers) is a non-hierarchical, multi-disciplinary, multi-national collaboration of physicians, surgeons,
scientists and centers of excellence around the world.
We value equality, diversity and inclusion and focus on scientific output with the highest possible
impact for our patients and the field.
We offer a platform for international collaboration under the umbrella of an IRB approval for multi-
center data analysis from the University College London IRB/Research Ethics Committee with further
local approval from all institutions. This allows us to publish the largest datasets on sinonasal cancers,
nasopharyngeal cancer, skull base tumors and brain cancers in order to inform on clinical outcomes,
improved staging systems and novel biomarkers.
Our aim is that the network’s collaborative research output (below publications) guide national and
international organizations when establishing updated guidelines on the diagnosis and management
of these malignancies. Moreover, INSICA-Brain has also been advocating the harmonisation of
prospective data collection between various large collaborations with the aim to create even larger,
global datasets on many orphan diseases.
Resulting guidelines may differ between high-income countries and low and middle-income countries
(LMICs) based on local resources and differences in the way healthcare is provided. We make every
effort to include data from LMICs and work closely with friends and colleagues, health care providers
and charitable organizations (foundations), such as the Association for the Global Advancement of
ENT Surgery and Head and Neck Cancer Research (AGA-ENT; www.aga-ent.org) in order to provide
the relevant data on companion diagnostic and prognostic biomarkers locally.
As the INSICA-Brain Network, we have already published key publications, e.g. on the largest
datasets on olfactory neuroblastoma, sinonasal melanoma, etc. published, to date. Please see links
below.
Ongoing and published work by INSICA:
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
https://pubmed.ncbi.nlm.nih.gov/33402692/
Clinical Outcomes, Kadish-INSICA Staging and Therapeutic Targeting of SSTR2 in Olfactory Neuroblastoma
https://pubmed.ncbi.nlm.nih.gov/34980502/